fran-romero-campero/ATTRACTOR: Fiesta release of ATTRACTOR

The circadian clock and light signalling play central roles in plant physiology and development. As a consequence, massive amounts of omics data have been generated to characterize their individual components. Nonetheless, these data remain fragmented and researchers who want to explore the synergistic regulation exherted by the circadian clock and light signalling need to consult different papers and resources making imperative the use of molecular systems biology techniques to integrate and make easily accesible all the generated information. ATTRACTOR, is a web based tool for the analysis of the synergistic transcriptional control exherted by the circadian clock and light signalling over genes exhibiting rythmic expression profiles in the model plant Arabidopsis thaliana. ATTRACTOR, consists of a transcriptional network that integrates transcriptomic data collected over diurnal cycles with 12 hours of light and 12 hours of darkness with cistromic data generated using ChIP-seq for key transcriptional factors and regulators in the circadian clock and light signalling. Specifically, our network is composed of 5778 nodes or genes with diurnal rythmic expression profiles and 14529 edges or transcriptional regulations. The transcription factors and regulators included in our network comprise the components of the morning and central loops CCA1, LHY, the pseudo response regulator family members TOC1,PRR5, PRR7 and PRR9; as well as some components of the evening loop such as LUX, ELF3 and ELF4. In order to capture synergistic regulations with light signalling we added the light sensors and transcriptional regulators phytochromes PHYA and PHYB, the cryptochrome CRY2 as well as the light transcriptional factors from the phytochrome interacting factor family PIF5, PIF4 and PIF3. Finally, the phytochrome interacting transcriptional factor FHY1 (Far-red elongated Hypocotyl 1) is also included in our network.