LayNii: A software suite for layer-fMRI

Published March 5, 2026 | Version v2.10.0

Software Open

New programs

LN2_FRISGO: This program corrects/mitigates the Fuzzy Ripple artifacts in dual polarity 3D-EPI fMRI data.
LN2_ZSCORE: Simple z-scoring for time series data.
LN2_DESPIKE: Developed mainly for 3D EPI FRISGO data, where moving tissue (e.g. eyeballs) can partially affect the images.
LN2_RECIPROCAL: Simple reciprocal with a few convenience options.
LN2_SNAPCAST: Cardinal axis projection for quick surface visuals.

We added 64 bit compatibility that is needed to process very large datasets (>5 gb) for the following programs:

LN2_FRISGO: Completely revised and improved with 64 bit compatibility. Also there is a new -simple flag for the simplest dual polarity correction that developed for dataset with regional spikes (see the new LN2_DESPIKE program).
LN2_SENSITIVITY: Added 64 bit compatibility.
LN2_SPECIFICITY: Added 64 bit compatibility.
LN2_GRAMAG: Added 64 bit compatibility.

If you use this software, please cite it as below.

Name	Size	Download all
layerfMRI/LAYNII-v2.10.0.zip md5:2023e2b24470244134877eab00c56e63	92.7 MB	Preview Download

Is supplement to: Software: https://github.com/layerfMRI/LAYNII/tree/v2.10.0 (URL)