Published March 26, 2020
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Fig. 3 in Identifying SARS-CoV-2related coronaviruses in Malayan pangolins
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Fig. 3 | Analysis of the receptor-binding domain (RBD) sequence. (A) Sequence alignment showing the RBD in human,pangolin and bat coronaviruses.The five critical residues for binding between SARS-CoV RBD and human ACE2 protein are indicated in red boxes, and ACE2-contacting residues are indicated with yellow boxes,following Wan et al.9. Note that in Guangdong pangolin sequence,the codon positions coding for amino acids 337 proline,420 aspartic acid, 499 proline and 519 asparagine have ambiguous nucleotide compositions, resulting in possible alternative amino acids at these sites (threonine,glycine,threonine and lysine,respectively).GD:Guangdong, GX:Guangxi.(B) Phylogenetic trees of the SARS-CoV-2 related lineage estimated from the entire RBD region (upper) and synonymous sites only (lower).Branch supports obtained from 1,000 bootstrap replicates are shown.
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Published as part of Lam, Tommy Tsan-Yuk, Shum, Marcus Ho-Hin, Zhu, Hua-Chen, Tong, Yi-Gang, Ni, Xue-Bing, Liao, Yun-Shi, Wei, Wei, Cheung, William Yiu-Man, Li, Wen-Juan, Li, Lian-Feng, Leung, Gabriel M., Holmes, Edward C. & Guan, Yi, 2020, Identifying SARS-CoV-2related coronaviruses in Malayan pangolins, pp. 1-15 in Nature 2020 on page 5, DOI: 10.1038/s41586-020-2169-0, http://zenodo.org/record/3737525
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- Journal article: 10.1038/s41586-020-2169-0 (DOI)
- Journal article: urn:lsid:plazi.org:pub:AD5BFFF2FFA6FFFC7E236F6DC61F9758 (LSID)
- Journal article: http://publication.plazi.org/id/AD5BFFF2FFA6FFFC7E236F6DC61F9758 (URL)
- Journal article: https://zenodo.org/record/3737525 (URL)