Dataset related to the article: "IS THE PLACENTAL PROTEOME IMPAIRED IN WELL-CONTROLLED GESTATIONAL DIABETES?"
Authors/Creators
- 1. Università di padova, Dipartimento di Scienze ediche e Chirurgiche
- 2. Centro Cardiologico Monzino , IRCCS
- 3. University of Padova, Italy, Department of Woman's and Child's Health
- 4. Institute of Paediatric Research, LAB NIB
Description
This record contains raw data related to the article" IS THE PLACENTAL PROTEOME IMPAIRED IN WELLCONTROLLED GESTATIONAL DIABETES?"
ABSTRACT
In pregnancy complicated by gestational diabetes (GDM), the human placenta shows several pathological functional and structural changes, but the extent to which maternal glycemic control contributes to placental abnormalities remains unclear. The aim of this study was to profile and compare the proteome of placentas from healthy pregnant women and those with GDM, to investigate the placenta-specific protein composition and possible changes of its function in presence of GDM. Quantitative proteomic analysis, based on LC-MSE approach, revealed that higher (≈15% increase) levels of galectin 1 and collagen alpha-1 XIV chain (although the difference regarding the latter was at the limit of significance) were present in GDM samples, while heat shock 70 kDa protein 1A/1B was less abundant in GDM placental tissue. These data seem to indicate that GDM, when well-controlled, did not markedly affect the placental proteome.
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Related works
- Is supplement to
- Journal article: 10.1002/jms.4336 (DOI)