Association between Glycemic Control and Lipid Profile in Adults with Type 2 Diabetes Mellitus

Background: Diabetes mellitus is the most common metabolic disease. Impaired lipid metabolism resulting from uncontrolled hyperglycemia has been implicated in cardiovascular complications in diabetic patients. Also, glycosylated hemoglobin (HbA1c) has been regarded as an independent risk factor for cardiovascular disease. Objective: The aim of this study was to examine the correlation between HbA1c, fasting blood sugar (FBS) with serum lipid levels in type 2 diabetes mellitus (T2DM). Subjects and Methods: Venous blood samples were collected from 84 type 2 diabetic patients as well as 42 age and sex matched apparently healthy control. Blood samples of all participants were analyzed for HbA1c and fasting blood glucose (FBG). Serum was analyzed for lipid profile including: total cholesterol (TC), triacylglycerol (TAG); low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C). TC/HDL-C ratio as well as HDL-C/LDL-C ratio was calculated. Results: All lipid parameters were significantly altered in T2DM patients as compared to normal control. Moreover, Patients with uncontrol diabetes (UCD) had significantly higher levels of FBG and lipid parameters than those with WCD. No significant difference in lipid parameters was found between both genders, except for TC/HDL-C ratio and HDL-C/LDL-C ratio of PCD females