ANAIS DO XII SIMPÓSIO DE ENGENHARIA BIOMÉDICA - IX SIMPÓSIO DE INSTRUMENTAÇÃO E IMAGENS MÉDICAS (ISSN: 2358-3568)
Published September 25, 2019 | Version v1
Conference paper Open

Distinct Parkinson's Disease Symptoms Relates To Different LFP Frequency Bands

Authors/Creators

  • 1. Center of Engineering, Modeling and Applied Social Sciences (CECS) Federal University of ABC São Bernardo do Campo, Brazil
  • 2. Division of Eletronic Engineering Aeronautics Institute of Technology São José dos Campos, Brazil
  • 3. Neurology and Functional Neurosurgery Division Santa Marcelina Hospital São Paulo, Brazil
  • 4. Functional Neurosurgery Division University of São Paulo São Paulo, Brazil

Description

Parkinson’s Disease (PD) leads to heterogeneous clinical symptoms. The underlying electrophysiological phenomena in the basal ganglia circuit remains poorly understood, imposing a major challenge for designing customized and more efficient Deep Brain Stimulation (DBS) protocols to match patients’ specificities and needs. To fill this gap, this work presents the correlation between clinical symptoms scores and spectral features evaluated from subthalamic nucleus (STN) local field potentials (LFP) recorded during intraoperative surgery for electrodes implantation in different PD subtypes. In addition to that, a linear regression model was designed and used to predict the symptoms scores (tremor, rigidity and bradykinesia) based on LFP rhythm’s power. The findings may help to understand how the spectral STN characteristics relate to PD clinical symptoms and guide new DBS paradigms.

Notes

XII SIMPÓSIO DE ENGENHARIA BIOMÉDICA - IX SIMPÓSIO DE INSTRUMENTAÇÃO E IMAGENS MÉDICAS

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