Published March 15, 2018 | Version v1
Journal article Open

Comprehensive subcellular topologies of polypeptides in Streptomyces

  • 1. Laboratory of Molecular Bacteriology, Dpt. of Microbiology and Immunology, Rega Institute, KU Leuven
  • 2. Department of General Biology, School of Medicine, Univer‑ sity of Patras
  • 3. Institute of Molecular Biology and Biotechnology-FORTH
  • 4. Center for Biotechnology (CeBiTec), Universität Bielefeld
  • 5. Department for Cellular and Molecular Medicine, KU Leuven,
  • 6. FORTH / ICE-HT

Description

Members of the genus Streptomyces are Gram-positive bacteria that are used as important cell factories to produce secondary metabolites and secrete heterologous proteins. They possess some of the largest bacterial genomes and thus proteomes. Understanding their complex proteomes and metabolic regulation will improve any genetic engineering approach.

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Funding

European Commission
MANGO - The determinants of cross-seeding of protein aggregation: a Multiple TANGO 647458