Sequence Data for Templated Mutagenesis Analysis

This repository contains the sequence data required for the analysis of templated mutagenesis.

The sequences in the ebola folder are described in  Bornholdt et al., "Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak" (dx.doi.org/10.1126/science.aad5788). The associated SRA accession numbers are listed in ebola/ebola_accessions_heavy.txt.

The sequences in the yeap folder are described in Yeap et al., "Sequence-Intrinsic Mechanisms that Target AID
Mutational Outcomes on Antibody Genes" (http://dx.doi.org/10.1016/j.cell.2015.10.042). The associated SRA accession numbers are listed in yeap/SRR_Acc_List_gpt.txt.

The sequences in the reference_sets folder are derived from IMGT (http://www.imgt.org/vquest/refseqh.html) and Retter et al., "Sequence and Characterization of the Ig Heavy Chain Constant and Partial Variable Region of the Mouse Strain 129S1" (https://doi.org/10.4049/jimmunol.179.4.2419). More information about how the sequences were accessed and processed is available in reference_sets/README.md.