THE CORRELATION BETWEEN PROINSULIN/ INSULIN RATIO AND ADIPONECTIN RECEPTOR LEVEL AFTER GIVING THE PUGUNTANO LEAF EXTRACT (Curanga fel-terrae Merr.) IN TYPE 2 DIABETES WISTAR RAT

Introduction: Diabetes mellitus (DM) is a chronic condition characterized by high blood glucose concentration resulting from insufficient insulin production and/ or ineffective insulin action. Proinsulin was synthesized and secreted as a insulin precursor and marker predictor of type 2 DM. Adiponectin has a contributory role in insulin sensitivity through decrease of hepatic gluconeogenesis and increased glucose transport in muscles.

Method: An experimental study, conducted from April to August 2018 at unit of research laboratory of Faculty of medicine in Padjadjaran University, Bandung. The samples were Rat Wistar Strain of type 2 diabetes mellitus (T2DM) model was divided into 2 groups: control group and experimental group. Experimental group was given Puguntano extract. Correlation between proinsulin/ insulin ratio and adiponectin receptor after giving Puguntano leaf extract was analysed with  using Spearman correlation. Changes that occurred were assessed with p value of <0.05 was considered statistically significant.

Result: This study did for 48 Rat Wistar Strain of T2DM model divided into 2 groups: control group dan experimental group. The correlation between Proinsulin/ insulin ratio and adiponectin receptor is negative correlation with correlation coefficient r=-0,254 and p value p=0,231. This result shown that non significant in statistical analysis on this study (p>0,05).

Conclusion: There is no significant correlation between proinsulin/ insulin ratio and adiponectin receptor after giving the Puguntano leaf extract (Curanga fel-terrae Merr.) in type 2 Diabetes Mellitus Wistar rat.