Morphological features of liver effect in patients with chronic hepatitis B with HIV-coinfection

Soni S. Ch., Moroz L. V., Havrylyuk A. O., Chichirelo-Konstantynovych K. D. Morphological features of liver effect in patients with chronic hepatitis B with HIV-confection. Journal of Education, Health and Sport. 2019;9(6):503-513. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.3270603

http://ojs.ukw.edu.pl/index.php/johs/article/view/7135

The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26/01/2017).

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

© The Authors 2019;

This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland

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Received: 10.06.2019. Revised: 24.06.2019. Accepted: 27.06.2019.

MORPHOLOGICAL FEATURES OF LIVER EFFECT IN PATIENTS WITH CHRONIC HEPATITIS B WITH HIV-COINFECTION

S. Ch. Soni, L. V. Moroz, A. O. Havrylyuk, K. D. Chichirelo-Konstantynovych

National Pirogov Memorial Medical University, Vinnytsya, Ukraine

Abstract

The article presents modern views on morphological disturbances in liver tissue at HBV/HIV patients. It was shown that "matte-glass-like" hepatocytes, inflammatory cell lymphocytic infiltrate of varying degrees and liver fibrosis are specific signs of HBV/HIV patients. Specific morphological signs of liver damage in co-infected patients confirm that HIV-infection worsens histological structure as well as functional balance. Therefore, development of pathohistology method of diagnostics becomes more and more necessary in patients with complicated liver injuries. New findings can give opportunity for early screening HBV-infected patients for HIV-markers, prescribing antiviral treatment at early stages. The research will build new approach for avoiding fast fibrogenesis.

Key words: HBV/HIV co-infection, "matte-glass-like" hepatocytes, liver fibrosis.