REALIZATION OF NEUROTRANSMITTER EFFECTS THROUGH THE CYCLASE CASCADE AND THE SYSTEM "SECONDARY MESSENGERS" UNDER THE CONDITIONS OF PROLONGED SUBTOXIC EFFECTS LAPROXIDE

Kucheriavchenko M. REALIZATION OF NEUROTRANSMITTER EFFECTS THROUGH THE CYCLASE CASCADE AND THE SYSTEM “SECONDARY MESSENGERS” UNDER THE CONDITIONS OF PROLONGED SUBTOXIC EFFECTS LAPROXIDE. Актуальні проблеми транспортної медицини / Actual problems of transport medicine / 2019;2(56):121-125. ISSN 1818-9385

DOI http://dx.doi.org/10.5281/zenodo.3251595

http://aptm.org.ua

REALIZATION OF NEUROTRANSMITTER EFFECTS THROUGH THE CYCLASE CASCADE AND THE SYSTEM “SECONDARY MESSENGERS” UNDER THE CONDITIONS OF PROLONGED SUBTOXIC EFFECTS LAPROXIDE

M. Kucheriavchenko

Kharkov National Medical University

Shevtsova_marina@ukr.net

Summary

The article deals with the study of impact, exerted by laproxide L-303 (triglycidyl polyoxipropylentriol ether) in 1/100 and 1/1000 LD50 on receptor bonding indices and intracellular mediator cyclase cascade in the settings of subtoxic continuous exposure on the body of homoeothermic animals. Laproxide L-303 in 1/100 LD50 was shown to exert membranotropic effects, which is indicated by a reduction in adenylate cyclase activity and cAMP contents, as well as an increase in guanylate cyclase and cGMP activity in the brain and liver. The assessment of glutamate/guanylate cyclase mediator cascade metabolic system condition in the liver showed an increase in both glutamate and guanylate cyclase mediator cascade, while in the brain glutamate was found to be decreasing in the settings of guanylate cyclase mediator cascade increase. Therefore, it is possible to conclude that laproxide L-303 in 1/100 LD50 is responsible for profound reconstruction of intracellular metabolism regulation systems, interfering with kinetic characteristics of radioligand receptor bonding indices in the settings of inhibition of adenyle cyclase and activation of guanylate cyclase mediator cascade. In 1/1000 LD50 laproxide was not found to have an effect on intracellular metabolism regulation systems.

Keywords: Xenobiotics, mediator cascade, homeostasis, membranotropic effect.