Enhancement Of Solubility And Dissolution Of Quetiapine By Recrystallization

Quetiapine an antipsychotic agent, exhibits poor aqueous solubility, dissolution and flow properties. Thus, the aim of the present study was to improve the solubility and dissolution rate of Quetiapine through re-crystallization method by solution evaporation technique using ethanol. The prepared formulation containing different ratios of drug was evaluated for solubility and in-vitro dissolution. The prepared formulations were characterized by UV method. Dissolution profile of the prepared crystals was compared with its physical mixture and pure sample. In the presented investigation Quetiapine exhibited appreciable decrease in pH (4.3-5.8) recrystallized in 100%, 90%, 75% & 50% ethanol. The formation of crystalline structure is smaller in size as compared to 100%, 90%, & 75% ethanol. The decrease in pH indicates. Environment of more hydrogen atom during recrystallization stage Quetiapine exhibits increase in dissociation constant value around (10-12.05%) in 100%, 90%, 75% & 50% ethanol. The dissolution kinetics of Quetiapine decreased with addition of water in recrystallizing solvent. The study indicates the recrystalline solvent plays an importance role in designing of physiochemical properties of the drug