Antimicrobial Evaluation of Pyridine Calix[6]arene Derivative and its Complexation Ability with Cd(II) Ions

Calixarenes are macrocyclic molecules composed of n phenolic unities linked with methylene bridges in the ortho positions. Their derivatives have been attracting much attention as interesting host compounds. These cyclic phenolic oligomers can easily be functionalized. The selectivity of calixarenes for alkali, alkaline earth and transition metal ions has led to the development of cation-selective electrodes.  In this study, pyridine calix[6]arene derivative was synthesised according to our article. The lower rim functionalization of calixarene with pyrazole has been chosen to design a moiety with the effective electron density. Oxygen and nitrogen atoms in calixarene are efficient to bind with Cd(II) ions. The synthesised calixarene derivative showed significant antimicrobial activity against Staphylococcus aureus (ATCC 6538), Pseudomonas aeruginosa (ATCC 9027), Aspergillus brasiliensis (ATCC 16404)  and Penicillium citrinium (ATCC 9849). In addition, pyridine calix[4]arene derivative ( ligand 1) has complexation ability to form 1:2 complex with Cd(II) ions.