Cytotoxic Antimicrobial Activity of Dehydrozingerone based Cyclopropyl Derivatives
Authors/Creators
- 1. Department of Biology and Ecology, Faculty of Science, University of Kragujevac, Radoja Domanovića 12, 34000 Kragujevac, Serbia
- 2. Vinča Institute of Nuclear Sciences, University of Belgrade, P.O. Box 522, RS-11001 Belgrade
- 3. National Poison Control Centre, Military Medical Academy, Crnotravska 17, RS-11000 Belgrade
- 4. Institute for Oncology and Radiology of Serbia, Belgrade
- 5. Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 67, RS-34000 Kragujevac and Public Health Institute Kragujevac, Nikole Pašića1, RS-34000 Kragujevac
Description
A small series of 1‐acetyl‐2‐(4‐alkoxy‐3‐methoxyphenyl)cyclopropanes was prepared, starting from dehydrozingerone (4‐(4‐hydroxy‐3‐methoxyphenyl)‐3‐buten‐2‐one) and its O‐alkyl derivatives. Their microbiological activities toward some strains of bacteria and fungi were tested, as well as their in vitro cytotoxic activity against some cancer cell lines (HeLa, LS174 and A549). All synthesized compounds showed significant antimicrobial activity and expressed cytotoxic activity against tested carcinoma cell lines, but they showed no significant influence on normal cell line (MRC5). Butyl derivative is the most active on HeLa cells (IC50 = 8.63 μm), while benzyl one is active against LS174 and A549 cell lines (IC50 = 10.17 and 12.15 μm, respectively).
Files
Cytotoxic and Antimicrobial Activity of Dehydrozingerone based Cyclopropyl Derivatives .pdf
Files
(2.2 MB)
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Additional details
Related works
- Has part
- 1612-1880 (ISSN)
- Is identical to
- 28388815 (PMID)
Funding
- Ministry of Education, Science and Technological Development
- Novel Electrochemical and Chemical Methods in Synthesis of Organic Compounds of Interest for Medicine and Material Chemistry 172034