Pathway Activation Strength (PAS) analysis of microarray data reveal similarities of aging with age-related macular degeneration and Hutchinson-Gilford progeria ? should aging be considered as a disease?

Aging is a complex multifactorial process leading to loss of function and age-related diseases. However, the contribution of aging to age-related diseases is still poorly understood. In this research study we compared differential tissue-specific pathway activation profiles in normal aging with progeria, Age-related Macular Degeneration (AMD). We discovered the age-related diseases share similarity with healthy aging at the signaling pathways level