Published July 1, 2019
| Version v1
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Therapeutic efficacy of glial cell-derived neurotrophic factor loaded collagen scaffolds in ex vivo organotypic brain slice Parkinson's disease models.
Creators
- 1. Laboratory of Psychiatry and Experimental Alzheimer's Research, Medical University of Innsbruck, Austria
Description
The paper evaluates neuroprotective effects of GDNF loaded collagen scaffolds in 3 ex vivo models: axotomy, rotenone and 6-OHDA. GDNF released from collagen scaffolds significantly protected dopaminergic SN neurons against axotomy and rotenone (50 nM, 14 days) induced cell death and showed a tendency of neuroprotection in 6-OHDA (5 mM, 10 min) lesions.
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