Published May 15, 2019 | Version v1
Dataset Open

Genetic variants (chr. 6) from Old World Schistosoma mansoni exomes

Authors/Creators

  • 1. Texas Biomedical Research Institute

Contributors

Project leader:

  • 1. Texas Biomedical Research Institute
  • 2. National Institute for Medical Research
  • 3. London Centre for Neglected Tropical Disease Research
  • 4. Réseau International Schistosomiases Environnemental Aménagement et Lutte
  • 5. Directorate General of Health Services
  • 6. Sultan Qaboos University
  • 7. University of Perpignan
  • 8. University of Texas Health Science Center at San Antonio

Description

Variant calling file (VCF) produced from exome libraries of Schistosoma mansoni (bloodfluke) samples from the Old Wold (West Africa (Senegal, Niger), East Africa (Tanzania), and Middle East (Oman)). One sample form the New World (Caribbean (HR9)) was added for comparison. The variants were called on the 3 Mb of chromosome 6 centered on the SmSULT-OR gene. This gene is involved in resistance to the drug oxamniquine  (OXA). The aim of the related article was to investigate the origin of OXA resistant mutations in the New Wolrd by identifying sequence variation in SmSULT-OR in S. mansoni from the Old World, where OXA has seen minimal usage.

Notes

For technical details, please see the related article.

Files

Files (57.0 MB)

Name Size Download all
md5:57ab9157c1cce8091894a3142f69db56
57.0 MB Download

Additional details

Funding

National Institutes of Health
Genetic Analysis of Host Specificity in Schistosoma mansoni 5R01AI097576-02
Wellcome Trust
SCAN: The Schistosomiasis Collections at the Natural History Museum. 104958
National Institutes of Health
Efficient Linkage Mapping Methods for Schistosoma mansoni 5R21AI096277-02

Subjects

Schistosoma mansoni
https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=6183