miR-125a-5p Inhibits Tumorigenesis in Hepatocellular Carcinoma by Targeting PTPN1 and MAP3K11 via the MAPK Signaling Pathway
Authors/Creators
- 1. Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200071, P.R. China
- 2. Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200071, P.R. China;Institute for Thoracic Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, 200030, P.R. China
- 3. Institute for Thoracic Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, 200030, P.R. China;Department of Clinical Laboratory Medicine, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200071, P.R. China
Description
Supplementary material: Table S1. A list of primers used in the qRT-PCR reactions. Supplementary material: Table S2. The sequences of the mimics, inhibitors, and siRNAs. Supplementary material: Table S3 The 131 common elements in the "DIANA-microT" "miRDB" and "TargetScan" database. Supplementary material: Table S4 The correlation of PTPN1 and MAP3K11 protein expression with clinicopathologic features. Supplementary material: Table S5 PTPN1 expression level between HCC and normal liver tissues. Supplementary material: Table S6 MAP3K11 expression level between HCC and normal liver tissues. Figure S1. miR-125a-5p suppresses proliferation and induces apoptosis in HCC cells in vitro. Figure S2. PTPN1 and MAP3K11 are direct targets of miR-125a-5p in HCC. Figure S3. PTPN1 and MAP3K11 are up-regulated and negatively correlate with the expression of miR-125a-5p in HCC. Figure S4. miR-125a-5p suppresses cell proliferation and induces apoptosis in HCC by targeting PTPN1 and MAP3K11 via the MAPK signaling pathway.
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