Changes of microelement homeostasis when modeling HIPEC with cisplatine

Pykhtieieva E. D., Gozhenko A. I., Pykhtieieva E. G., Bolshoy D. V., Tretyakov A. M. Changes of microelement homeostasis when modeling HIPEC with cisplatine. Journal of Education, Health and Sport. 2019;9(2):569-577. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.2652041

http://ojs.ukw.edu.pl/index.php/johs/article/view/6865

The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26/01/2017).

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

© The Authors 2019;

This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland

Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.

(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.

The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 05.02.2019. Revised: 11.01.2019. Accepted: 28.02.2019.

CHANGES OF MICROELEMENT HOMEOSTASIS WHEN MODELING HIPEC WITH CISPLATINE

E. D. Pykhtieieva, A. I. Gozhenko, E. G. Pykhtieieva, D. V. Bolshoy, A. M. Tretyakov

Ukrainian Research Institute of Transport Medicine, Odessa, Ukraine

Abstract

HIPEC was simulated on laboratory rats using cisplatin (CP) at a dose of 4 mg/kg. It has been shown that perfusion of a hot and cold solution of CP changes the accumulation of platinum and the concentration of heavy metals in organs (liver, kidney, spleen, blood) in different ways. An acute HIPEC simulation experiment shows that in a fairly short exposure time, critical absorption of platinum into the blood from the abdominal cavity does not occur, although the concentration of platinum in the blood is still growing. At the same time, Pt was found on the surface of parenchymal organs and the peritoneum of rats after the end of the experiment. This platinum is closely related to the surface and is not removed during the washing process. This suggests that the general toxic effect of platinum is less pronounced and delayed than with intravenous administration, but it will certainly occur through further interorgan redistribution.

Keywords: HIPEC, cisplatin, copper, zinc, cadmium, lead, platinum