ANTI-INFLAMMATORY ACTIVITY OF COMPLEX COMPOUNDS TIN (IV) CHLORIDE (SnCl4) WITH SALICYLOYL HYDRAZONES BENZALDEHYDE AND 4-BROMOBENZALDEHYDE ON CARRAGEENAN AND FORMALIN-INDUCED INFLAMMATION

Prokopchuk E. G, Aleksandrova I. O., Kravchenko І. A. ANTI-INFLAMMATORY ACTIVITY OF COMPLEX COMPOUNDS TIN (IV) CHLORIDE (SnCl4) WITH SALICYLOYL HYDRAZONES BENZALDEHYDE AND 4-BROMOBENZALDEHYDE ON CARRAGEENAN AND FORMALIN-INDUCED INFLAMMATION. Актуальні проблеми транспортної медицини / Actual problems of transport medicine / 2019;1(55):64-70. ISSN 1818-9385

DOI http://dx.doi.org/10.5281/zenodo.2611268

http://aptm.org.ua

УДК 541.49: 547.288.3: 615.276.

ANTI-INFLAMMATORY ACTIVITY OF COMPLEX COMPOUNDS TIN (IV) CHLORIDE (SnCl4) WITH SALICYLOYL HYDRAZONES BENZALDEHYDE AND 4-BROMOBENZALDEHYDE ON CARRAGEENAN AND FORMALIN-INDUCED INFLAMMATION

Prokopchuk E.G, Aleksandrova I.O., Kravchenko І.A.

Odessa National Polytechnic University, Odessa, Ukraine

e-mail pochtawt@me.com

Summary

Anti-inflammatory properties of new complexes of SnCl4 with benzaldehyde and 4-bromobenzaldehyde salicyloyl hydrazones the were studied in the rats using models on carrageenan and formalin-induced inflammation of paw. Solutions of benzaldehyde, 4-bromobenzaldehyde and salicylic acid were also used to determine their contribution to the anti-inflammatory activity of the complexes. The development of inflammatory process was assessed by changes in the volume and width of the inflamed paw. The use of complexes of SnCl4 with benzaldehyde and 4- bromobenzaldehyde salicyloyl hydrazones for treatment resulted in normalization of the width and volume of the inflamed paw following 3 days of treatment. . Six days after the start of the experiment (carrageenan model), the volume of the affected limb almost reached the control values in animals that received complex compounds I and II, benzaldehyde and salicylic acid. During the experiment it was determined that complex compounds I and II demonstrated the best anti-inflammatory activity in both models of inflammation

Key words: anti-inflammatory activity, complex compound, benzaldehyde, carrageenan, formalin.