Bar Ilan University
Published March 7, 2019 | Version v1
Journal article Open

Trimodal Nanoparticle Contrast Agent for CT, MRI and SPECT Imaging: Synthesis and Characterization of Radiolabeled Core/Shell Iron Oxide@Gold Nanoparticles

Authors/Creators

  • 1. Bar Ilan University
  • 2. Tel Aviv University
  • 3. NCSR Demokritos

Description

Recently, nanoparticles have emerged as promising contrast agents for various imaging applications. In this paper, we present the synthesis and characterization of a novel hybrid nano-structure, consisting of an iron oxide@gold nanoparticle, labeled with technetium-99m, for trimodal SPECT/CT/MRI imaging. The particles showed efficient capabilities as CT/MRI imaging agent and high radiochemical yield, indicating a potential single hybrid material for multimodal SPECT/CT/MRI.

Notes

Deposited is the final draft (prior to formatting/author proofreading), per the Journal's guidelines. Copyright belongs to the Chemical Society of Japan.

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Additional details

Funding

European Commission
nTRACK - Multimodal nanoparticles for structural and functional tracking of stem cell therapy on muscle regeneration 761031