Paraoxonase 1 as an important antiatherogenic agent

Krzewicka-Romaniuk Ewa, Siedlecka Dagna, Warpas Anna, Wójcicka Grażyna. Paraoxonase 1 as an important antiatherogenic agent. Journal of Education, Health and Sport. 2019;9(1):133-143. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.2542320

http://ojs.ukw.edu.pl/index.php/johs/article/view/6476

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© The Authors 2019;

This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland

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Received: 03.01.2019. Revised: 11.01.2019. Accepted: 17.01.2019.

PARAOXONASE 1 AS AN IMPORTANT ANTIATHEROGENIC AGENT

Ewa Krzewicka-Romaniuk¹, Dagna Siedlecka¹, Anna Warpas¹, Grażyna Wójcicka¹

¹Department of Pathophysiology, Medical University of Lublin

ABSTRACT: The inverse relationship between High Density Lipoproteins (HDL) level and risk of ischaemic heart disease was proved by many epidemiological studies. Although the main mechanism of antiatherogenic activity of HDL is a reverse transport of cholesterol from peripheral tissues to the liver, HDL additionally carries some antioxidative enzymes like Paraoxonase 1 (PON1) which protects LDL and HDL lipoproteins from oxidative modification. A lot of antiatherogenic activities of HDL depends on PON1 activity.

KEY WORDS: PARAOXONASE, PON1, LIPOPROTEINS, HDL, ANTIATHEROGENIC