FORMULATION DEVELOPMENT AND EVALUATION OF CHEWABLE TABLET OF BENZOCAIN BY DIFFERENT BINDER CONCENTRATION

Benzocain is chemically described as ethyl ester of para amino benzoic acid having local anaesthetic activity.It is readily absorbed from mucous membrane and poorly absorption through the skin .In water and dilute acid it is sparingly soluble and in chloroform and ethanol it is very soluble. Generally its administration by oral route.In case of throat disorders the patients who cannot swallow tablets hence benzocain chewable tablets helps to improve patient compliance. Chewable tablets were prepared with PVP k30 binder with different concentration 20 %, 30% and 40 % Tablet prepared by wet granulation method were performed and evaluation is done for different parameters such as weight variation, Hardness, percent comprasability , Tapped density, friability , Content uniformity ,Disintegration etc. All parameters were found within specifications of 30 % binder concentration . Assay value limit were found with in limit 95% to 110%.