Scale up. Power on. Building a world-leading capability: UK CEiRSI presentation to the MHRA Chief Executive, University of Manchester, 18 November 2025

Slides presented by Professor Alejandro F. Frangi, Executive Director of the UK Centre of Excellence for In Silico Regulatory Science & Innovation (UK CEiRSI), during the visit of the Chief Executive of the Medicines and Healthcare products Regulatory Agency (MHRA) to the University of Manchester on 18 November 2025. The presentation sets out the case for in silico evidence in the regulation of medicines and medical devices, the Centre's approach and community, and the first wave of the UK CEiRSI In Silico Regulatory Airlock (2024 to 2025). Slide 28 lists the ten first-wave Airlock pilots and the manufacturers that convened them: nine on medical devices and one on vaccines. Third-party figures and logos remain the property of their owners and are acknowledged on the slides; they are not licensed for reuse by this record.