Real-World Evidence in Implant Dentistry and Oral Regeneration - A Medical Registry

The Registry for Real-World Evidence in Implant Dentistry and Oral Regeneration is maintained by the Center for eHealth in Reconstructive Dentistry, Clinic of Reconstructive Dentistry, University of Zurich (UZH), Switzerland. This record provides the core dataset and corresponding data dictionary defining the principal clinical domains captured within the Registry for patients receiving dental implant therapy at the Clinic of Reconstructive Dentistry, UZH.  

Clinical implant data have been routinely collected at UZH since 2002. The Registry has subsequently undergone systematic standardization and implementation within Research Electronic Data Capture (REDCap) to support structured and consistent data acquisition. The Registry was reviewed by the Cantonal Ethics Committee Zurich (AO_2025-00094). 

The Registry is designed as a longitudinal real-world data infrastructure for implant dentistry and oral regenerative procedures. Its scope includes benchmarking and longitudinal trend analyses, identification and recruitment of eligible patients for prospective randomized controlled trials (RCTs), conduct of registry-based clinical trials (RBCTs), target trial emulation (TTE), and the development of predictive models and multimodal data integration. More broadly, the Registry provides a structured data foundation for transforming routinely collected clinical information into reusable scientific resources and for supporting personalized, data-driven research in dental and oral healthcare. 

The core dataset encompasses the following clinical domains: