Incompatibility Kinetics of Topical Actives: Biochemical Pathways of Iatrogenic Dermal Barrier Degradation in Adolescent Populations

The effects of multi-step skincare routines advertised on social media is explored in this study, with a focus on young consumers who frequently mix strong topical products, without guidance from professionals. The study assesses the chemical interactions that occur when typical acne treatments, like retinoids, L-ascorbic acid (Vitamin C), and exfoliating acids (AHAs/BHAs), are administered consecutively. Adolescent skin is prone to incompatible chemical mixes because it experiences major hormonal changes that impact its oil content. Excessive layering of these products can cause severe irritation and intensify acne by damaging the skin's natural pH balance, suppressing vital protective lipids, and causing damage to skin barrier. By examining these chemical processes, the study highlights the changes brought about by product abuse and emphasises the need for simplified and scientifically verified skincare regimens for younger populations by connecting contemporary consumer trends with applied chemistry.