Amendment N2 to Paper 04: Revised clinic-level execution on CDC National ART Surveillance System (NASS) public datasets
Description
Amendment N2 registers a revised clinic-level execution of the CORGData ART outcome modeling protocol on the public clinic-level datasets of the CDC National ART Surveillance System (NASS), in response to the executed Amendment N1 result, which the amendment states in full with the criteria that produced it. The amendment rebuilds the predictor set as multi-year histories, extends the panel rule, revises the band-resolution modeling for the age bands Amendment N1 found not validated, and rebuilds the standardization limits on an estimated dispersion in place of the Poisson variance assumed under Amendment N1. The outcome definition, the cohort threshold, the aggregate-only reporting of outlier clinics, the governance provisions, and the frozen validation criteria discipline of Amendment N1 stand unchanged, and a pass under Amendment N2 cannot overturn the Amendment N1 verdict.
Files
zagadailov-2026-art-outcome-modeling-amendment-n2-nass.pdf
Additional details
Related works
- Is supplement to
- Preprint: 10.5281/zenodo.23541714 (DOI)
- References
- Preprint: 10.5281/zenodo.23598479 (DOI)
- Preprint: 10.5281/zenodo.23555694 (DOI)
References
- Zagadailov P. Predictive modeling of ART outcomes with the CORGData framework: a design and pilot protocol. Zenodo. 2026. https://doi.org/10.5281/zenodo.23541714
- Centers for Disease Control and Prevention. Accessing NASS data: NASS clinic-level datasets. Accessed October 24, 2026. https://www.cdc.gov/art/php/data-access/index.html
- Malizia BA, Hacker MR, Penzias AS. Cumulative live-birth rates with assisted reproductive technology. JAMA. 2009;301(3):271-276.
- Zagadailov P, Hsu A, Seifer DB, Stern JE. Differences in utilization of intracytoplasmic sperm injection (ICSI) within human services (HHS) regions and metropolitan megaregions in the U.S. Reprod Biol Endocrinol. 2017;15:45.
- Zagadailov P, Hsu A, Stern JE, Seifer DB. Temporal differences in utilization of intracytoplasmic sperm injection among U.S. regions. Obstet Gynecol. 2018;132(2):310-320.
- Zagadailov P, Seifer DB, Shan H, Zarek SM, et al. Do state insurance mandates alter ICSI utilization? Reprod Biol Endocrinol. 2020;18:33.
- Zagadailov P, Cho KS, Seifer DB. Differences in ICSI utilization rates among states with insurance mandates for ART coverage. Reprod Biol Endocrinol. 2021;19:174.
- Fertility Clinic Success Rate and Certification Act of 1992, Pub. L. No. 102-493 (1992).
- Collins GS, Reitsma JB, Altman DG, Moons KGM. Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD): the TRIPOD statement. BMJ. 2015;350:g7594.
- Spiegelhalter DJ. Funnel plots for comparing institutional performance. Stat Med. 2005;24(8):1185-1202.