HIDE-deconv: Hierarchical cell-type deconvolution and analysis of bulk RNA-seq data using single-cell references

HIDE-deconv is a Python package and command line interface for hierarchical cell-type deconvolution of bulk RNA-seq data using annotated single-cell references. It jointly estimates cellular compositions across multiple levels of a cell-type hierarchy and integrates reference construction, model training, deconvolution, statistical analysis and visualization.