From Candidate Hierarchy to Experimental Dependency Map: Post-HTP1.6 Updated Edition.

Post-HTP1.6 updated edition of the Theory of Everything Research Programme synthesis paper. The previously published Post-TP1 edition is preserved and followed by an addendum incorporating the prospective HTP1.6 matched-control adjudication. The original TP1-A result remains supported: causal self-maintenance emerged in all 40 preregistered artificial CRN populations. HTP1.6 then tested whether that external disturbance-recovery phenotype uniquely required the evolved catalytic architecture. Of 40 new targets, 21 obtained adequately matched non-catalytic expanded-passive controls and all 21 reproduced the held-out functional profile (bypass proportion 1.000; Wilson 95% CI approximately 0.845-1.000). The dependency map is therefore refined into TP1-A1 (causal self-maintenance emergence: SUPPORTED), TP1-A2 (catalytic architectural uniqueness/necessity: NOT SUPPORTED), and TP1-P (physical/protocellular transport: OPEN). TP2, TP3, TP4 and OP1 retain their previous statuses.