Processed and derived data for an androgen-derived transcriptional state revealing signaling and mitochondrial vulnerabilities in cancer

This dataset contains processed and derived data supporting the study of the androgen-suppressed transcriptional state (ASTS), a cross-species transcriptional state derived from the relative transcriptional response to dihydrotestosterone in mouse adrenal zona fasciculata cells and projected to human cancer cell lines. The dataset includes processed mouse RNA-seq data, frozen mouse and human ASTS signatures, ASTS scores across cancer cell lines, derived pharmacogenomic association results, CRISPR dependency analyses, mitochondrial dependency analyses, and robustness analyses. Original third-party datasets from DepMap, PRISM, GDSC2, CTRPv2, and MSigDB are not redistributed. Raw mouse RNA-seq data are available from the DNA Data Bank of Japan Sequence Read Archive under accessions DRA015952 and DRA017476. Analysis code and reproducibility documentation are available from the associated GitHub repository.