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Cardiovascular autonomic dysfunction is one of the most significant non-motor manifestations of Parkinson's disease (PD). Orthostatic hypotension (OH) holds a particular place in this context; it can be either symptomatic or asymptomatic and is associated with falls, impaired daily living activities, and reduced quality of life. The aim of the study was to assess the prevalence of orthostatic hypotension, the characteristics of its clinical manifestations, and its relationship with the duration and severity of Parkinson's disease. A single-center observational study was conducted involving 120 patients with a clinical diagnosis of Parkinson's disease. Patients with OH exhibited a more advanced mean disease stage, longer disease duration, and more pronounced motor and non-motor impairments. Orthostatic hypotension is a common non-motor manifestation of PD and can be observed even at relatively early stages of the disease. As PD progresses, the prevalence of OH and the severity of the orthostatic drop in blood pressure increase. Given the potential for an asymptomatic course, measuring blood pressure in both the supine and upright positions should be included in the routine neurological assessment of patients with PD.
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