Tissue Engineering Explained: Regenerative Medicine, Biomaterials & Medical Innovation

This open educational resource (OER) curriculum module provides an in-depth, mathematically and physically rigorous treatment of Tissue Engineering and Regenerative Medicine. Positioned at the intersection of cellular biology, transport phenomena, materials science, and clinical medicine, the module explores the engineering principles governing artificial tissue construct fabrication, vascularization, and in vivo host integration.

Key foundational topics include natural and synthetic scaffold polymers (collagen, PGA, PLLA, PCL), stem cell lineage commitment (MSCs, iPSCs), biochemical morphogen signaling (VEGF, BMPs), and perfusion bioreactor mechanics. The module bridges classical biotransport equations to contemporary 2026 computational paradigms, featuring:
- Physics-Informed Neural Networks (PINNs) solving coupled Brinkman-Darcy momentum and Fickian convection-diffusion-reaction equations with Michaelis-Menten cellular uptake, complete with a step-by-step numerical residual evaluation.
- An analytical derivation of the critical slab diffusion thickness limit (L_crit) preventing construct core hypoxia.
- A multi-variable systems engineering trade-off matrix analyzing scaffold architecture, degradation kinetics, bio-ink rheology, and cell sourcing.
- An interactive dynamic simulator modeling the temporal remodeling balance between scaffold mass decay and nascent extracellular matrix (ECM) deposition.
- Three tiers of self-assessment modules covering conceptual foundations, analytical scenarios, and quantitative calculations with step-by-step solutions.

Permanent web resource: https://prep4uni.online/stem/physical-technologies/biomedical-engineering/tissue-engineering-and-regenerative-medicine/