SANUM: Revista Científico-Sanitaria / Scientific-Health Journal
Published October 30, 2026 | Version v1
Journal article Open

PRODUCTOS FINALES DE GLICACIÓN AVANZADA: FORMACIÓN, MECANISMOS MOLECULARES Y SU IMPACTO EN LA SALUD METABÓLICA

Authors/Creators

  • 1. Universidad Internacional del Ecuador (UIDE). Ecuador.
  • 2. Pontificia Universidad Católica del Ecuador, sede Manabí. Manabí, Ecuador.

Description

Tipo de artículo: Artículo de revisión

Introducción: Los productos finales de glicación avanzada (AGEs) son compuestos generados por la reacción de Maillard, tanto en el organismo bajo condiciones de hiperglucemia o envejecimiento como durante la preparación térmica de alimentos. Su acumulación sostenida activa el receptor RAGE, desencadenando estrés oxidativo, inflamación crónica y daño tisular progresivo.

Objetivo: Revisar los mecanismos de formación, clasificación, rutas de absorción y el impacto fisiopatológico de los AGEs en enfermedades crónicas no transmisibles.

Materiales y métodos: Se realizó una revisión narrativa de la literatura en PubMed, Scielo y Google Scholar (2020–2024) mediante términos como "advanced glycation end products", "RAGE receptor", "glycation mechanisms" y "metabolic diseases".

Resultados: Los AGEs se forman por vías endógenas y exógenas; sus precursores reactivos, metilglioxal, glioxal y 3-desoxiglucosona,  generan modificaciones irreversibles en proteínas, lípidos y ADN. La interacción AGE-RAGE activa NF-κB, MAPK y TGF-β, amplificando el daño oxidativo. Se documentó su participación en diabetes, enfermedad renal crónica, aterosclerosis y obesidad.

Conclusiones: La acumulación de AGEs constituye un nexo molecular central entre la dieta, el metabolismo y las enfermedades crónicas. Reducir su ingesta dietética y optimizar los métodos de cocción representan estrategias preventivas con respaldo científico creciente.

Abstract (English)

Article type: Review article

Introduction: Advanced glycation end products (AGEs) are compounds generated through the Maillard reaction, occurring both endogenously under hyperglycemic or aging conditions and during thermal food processing. Their sustained accumulation activates the RAGE receptor, triggering oxidative stress, chronic inflammation, and progressive tissue damage.

Objective: To review the mechanisms of AGE formation, classification, absorption pathways, and their pathophysiological impact on chronic non-communicable diseases.

Materials and Methods: A narrative literature review was conducted in PubMed, Scielo and Google Scholar (2020–2024) using terms including "advanced glycation end products", "RAGE receptor", "glycation mechanisms", and "metabolic diseases".

Results: AGEs form through endogenous and exogenous pathways; reactive precursors, methylglyoxal, glyoxal, and 3-deoxyglucosone, cause irreversible modifications to proteins, lipids, and DNA. The AGE-RAGE axis activates NF-κB, MAPK and TGF-β, amplifying oxidative damage. Their involvement was documented in diabetes, chronic kidney disease, atherosclerosis, and obesity.

Conclusions: AGE accumulation represents a central molecular link between diet, metabolism, and chronic disease. Reducing dietary intake and optimizing cooking methods are preventive strategies with growing scientific support.

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Additional details

Additional titles

Translated title (English)
ADVANCED GLYCATION END PRODUCTS: FORMATION, MOLECULAR MECHANISMS AND THEIR IMPACT ON METABOLIC HEALTH

Dates

Collected
2026-06-16
manuscrito recibido
Accepted
2026-08-04
evaluación doble ciego
Available
2026-10-29
publicación en numero de la revista

Software

Repository URL
https://revistacientificasanum.com/
Development Status
Active

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