Published September 22, 2026 | Version v1
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RADICULAR CYSTS: DEVELOPMENTAL MECHANISMS, CLINICAL COURSE, DIAGNOSIS AND CONTEMPORARY MANAGEMENT — A NARRATIVE REVIEW OF CURRENT EVIDENCE

Authors/Creators

  • 1. 1 Faculty of Dentistry, Kimyo International University in Tashkent, Tashkent, Republic of Uzbekistan
  • 2. 2Scientific Supervisor, PhD, Associate Professor, Department of Therapeutic Dentistry, Kimyo International University in Tashkent, Tashkent, Uzbekistan.
  • 3. Worldly Knowledge Publishing Centre

Description

The radicular cyst is an inflammatory odontogenic cyst (ICD-10 K04.8) that develops within a chronic periapical inflammatory process arising from pulp necrosis and root canal infection. Its pathogenesis is considerably more complex than the formation of a mechanical cavity, arising from the interaction of microbial antigens, innate and adaptive immunity, proliferation of the epithelial cell rests of Malassez, growth factors, cytokines and bone remodelling.

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References

  • 1.Browne RM. The pathogenesis of odontogenic cysts: a review. J Oral Pathol. 1975;4(1):31–46. doi:10.1111/j.1600-0714.1975.tb01738.x
  • 2.Colić S, Jurišić M, Jurišić V. Pathophysiological mechanism of the developing radicular cyst of the jaw. Acta Chir Iugosl. 2008;55(1):87–92. doi:10.2298/ACI0801087C
  • 3.World Health Organization. International Statistical Classification of Diseases and Related Health Problems, 10th revision. K04 — Diseases of pulp and periapical tissues; K04.8 — Radicular cyst. Geneva: WHO.
  • 4.Johnson NR, Gannon OM, Savage NW, Batstone MD. Frequency of odontogenic cysts and tumors: a systematic review. J Investig Clin Dent. 2014;5(1):9–14. doi:10.1111/jicd.12044
  • 5.Nair PNR, Pajarola G, Schroeder HE. Types and incidence of human periapical lesions obtained with extracted teeth. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996;81(1):93–102. doi:10.1016/S1079-2104(96)80156-9