NLRP1 inflammasome axis in ulcerative colitis — analysis code, frozen six-gene coefficients and per-sample result tables

Code and key result tables accompanying the manuscript "Transcriptionalarchitecture of the human NLRP1 inflammasome axis in ulcerative colitis:a frozen six-gene program that tracks inflammatory state but is notgermline-driven — multi-cohort, cross-platform and single-cellevaluation". Contents: data download and preprocessing scripts (GEO seriesGSE59071/GSE48958/GSE73661/GSE87466/GSE94648/GSE107499; CELLxGENE IBDatlas), NLRP1-axis gene-set assembly, nested cross-validation withfrozen six-gene coefficients (ERBIN, CARD6, CASP4, MAP3K20, CASP6,IFI16), external and cross-platform validation, single-cell donor-levelpseudobulk, two-sample cis-MR and colocalization; per-sample scoretables, DE/AUC/immune-enrichment result tables, figure source files. All input data are public (GEO / CELLxGENE); no new data were generated.Archive and data/code queries: zhongy5008@163.com.