Antibacterial-activity, cytotoxicity, and physiochemical properties of tolfenpyrad analogs.

Analogs of the tolfenpyrad scaffold were synthesized through the functionalization of pyrazole-5-carboxamide and p-methylphenoxybenzyloxy moieties by employing two established reaction schemes to derivatize the left side (LS) and right side (RS) of tolfenpyrad. The resultant set of 262 closely-related analogs represents an array of physicochemical properties with substitutions on the LS, RS, and in the middle region (MR) of the tolfenpyrad scaffold