Published September 14, 2026 | Version 1.0

ComboBatch: a benchmark of transcriptomic harmonization methods for follicular lymphoma and DLBCL

Authors/Creators

  • 1. BostonGene, Corp., Waltham, MA, USA

Description

Code, metric tables and figures accompanying a systematic benchmark of transcriptomic batch-effect harmonization across 7,174 samples from 88 follicular lymphoma, DLBCL and normal B-cell cohorts spanning 19 platforms. 39 harmonization methods were implemented and 31 evaluated across 14 sample-removal strategies, 3 imputation modes and 2 post-removal variants, scored on 87 metrics in 14 groups, yielding a biomaterial- and platform-conditional decision tree for choosing a harmonization method.

Notes

If you use this software, the benchmark results, or the deposited tables, please cite both the article and this repository.

Files

Nikit357/FL_harmonization-1.0.zip

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