Published September 30, 2026
| Version 1.0
Dataset
Open
iSCORE-PD: scRNA-seq of WT WIBR3 hESC-derived dopaminergic neurons
Authors/Creators
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Busquets, Oriol1
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Li, Hanqin2
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Syed, Khaja Mohieddin3
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Alvarez-Jerez, Pilar4
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Dunnack, Jesse3
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Lo Bu, Riana5
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Verma, Yogendra3
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Pangilinan, Gabriella R.3
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Martin, Annika6
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Straub, Jannes3
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Du, YuXin3
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Simon, Vivien M.6
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Poser, Steven5
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Bush, Zipporiah7
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Diaz, Jessica5
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Sahagun, Atehsa8
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Gao, Jianpu6
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Hong, Samantha9
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Hernandez, Dena G.10
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Levine, Kristin S.9
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Pochet, Nathalie11
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Booth, Ezgi O.3
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Blanchette, Marco12
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Bateup, Helen S.13
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Rio, Donald C.3
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Blauwendraat, Cornelis14
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Hockemeyer, Dirk15
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Soldner, Frank16
- 1. Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Rose F. Kennedy Center, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA,& Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, 1301 Morris Park Ave., Bronx, NY 10461, USA,& Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815,USA
- 2. Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA,& Innovative Genomics Institute, University of California, Berkeley, CA, 94720, USA,& Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815,USA
- 3. Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA,& Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815,USA
- 4. Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, USA,& Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK
- 5. Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Rose F. Kennedy Center, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA,& Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815,USA
- 6. Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
- 7. Department of Genetics, Albert Einstein College of Medicine, 1301 Morris Park Ave., Bronx, NY 10461,USA,& Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815,USA
- 8. Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA,& Department of Neuroscience, University of California, Berkeley, Berkeley, CA 94720, USA,& Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815,USA
- 9. Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, USA
- 10. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD,20892, US.
- 11. Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Rose F. Kennedy Center, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA.
- 12. LiftOff Biosolution. 813 Isbel Ct, Santa Cruz 95060, USA.
- 13. Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA,& Department of Neuroscience, University of California, Berkeley, Berkeley, CA 94720, USA,& Chan Zuckerberg Biohub, San Francisco, CA, 94158, USA,& Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815,USA
- 14. Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, USA,& Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD,20892, US
- 15. Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA,& Innovative Genomics Institute, University of California, Berkeley, CA, 94720, USA,& Chan Zuckerberg Biohub, San Francisco, CA, 94158, USA,& Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815,USA
- 16. Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Rose F. Kennedy Center, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA,& Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, 1301 Morris Park Ave., Bronx, NY 10461, USA,& Department of Genetics, Albert Einstein College of Medicine, 1301 Morris Park Ave., Bronx, NY 10461,USA,& Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815,USA
Description
This Zenodo deposit contains a publicly available description of the Dataset:
Title: "iSCORE-PD: scRNA-seq of WT WIBR3 hESC-derived dopaminergic neurons".
Description: Single-cell RNA sequencing of WIBR3 hESC-derived dopaminergic neurons differentiated for 35-37 days. Three biological replicates were independently differentiated and assayed via CellPlex-multiplexed 10x Chromium v3.1 scRNA-seq libraries.
This dataset is made available to researchers via the ASAP CRN Cloud: cloud.parkinsonsroadmap.org. Instructions for how to request access can be found in the User Manual.
This research was funded by the Aligning Science Across Parkinson's Collaborative Research Network (ASAP CRN), through the Michael J. Fox Foundation for Parkinson's Research (MJFF).
This Zenodo deposit was created by the ASAP CRN Cloud staff on behalf of the dataset authors. It provides a citable reference for a CRN Cloud Dataset
Files
rio-hesc-sc-rnaseq-wt-dopaminergic_README.pdf
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Additional details
References
- Aligning Science Across Parkinson's Collaborative Research Network Cloud, https://cloud.parkinsonsroadmap.org/collections, RRID:SCR_023923
- Team Rio