Chapter 4 – The Energetic Basis of Physiology and General Metabolism

Instructor guide to Chapter 4 of Mechanisms and Logic in Human Physiology. Twenty sections build metabolism from thermodynamics rather than from pathway maps: physical law sets the limits, metabolism is the transfer of chemical bond energy within them, and each pathway is a specific case. Covers Gibbs free energy, exergonic-endergonic coupling, enzyme kinetics and pacemaker flux, glycolysis, the Krebs cycle, the electron transport chain, beta-oxidation, amino acid catabolism, metabolic rate and calorimetry, anabolism, and gluconeogenesis.