Analysis code for: Blood cis-eQTL Mendelian randomization nominates druggable targets for ovarian and other gynecologic cancers

Analysis pipeline for a drug-target Mendelian randomization study using whole-blood cis-eQTLs (eQTLGen, n = 31,684) to nominate druggable targets across gynecologic cancers.

Includes: single-instrument Wald ratio MR against a large ovarian cancer GWAS (23,564 cases) and an endometrial cancer GWAS (12,906 cases); multi-instrument IVW with MR-Egger and weighted-median sensitivity analyses; coloc.abf and multi-signal coloc.susie colocalization; a phenome-wide scan for on-target effects; and Open Targets druggability annotation.

All input data are publicly available (eQTLGen; GWAS Catalog GCST90016665 and GCST006464; FinnGen R12; Open Targets). 27 analysis scripts, 13 result tables, 5 figures.