PATIENTS OF DIABETES MELLITUS MAINTAINED ON ORAL HYPOGLYCEMIC DRUGS THE IMPORTANCE OF URINARY IgG AS A DIAGNOSTIC FACTOR FOR DIABETIC NEPHROPATHY

Objective: In patients on oral hypoglycemic drug type II aim to conclude urine IgG in diabetes as marker for early stages of diabetic nephropathy.

Study Design: A Retrospective Study.

Place and Duration: In the Nephrology Department of Mayo Hospital, Lahore for one-year duration from July 2017 to July 2018.

Methods: The study included 42 female patients and 27 male patients, age range 40-60 and long-term diabetic patients. Patients receiving oral hypoglycemic agents were taken from the internal and external medicine OPD. Electrophoretic models of 24-hour urine proteins in diabetic patients were investigated in polyacrylamide gel electrophoresis with a 10% SDS gradient. The 24-hour urine proteins of the patients were estimated.

Results: Electrophoretic profile showed proteinuria status (both high molecular weight and low molecular weight). There was a significant increase in the volume (concentration) and IgG density in the patient's urine.

Conclusion: Urinary excretion of IgG is an important prognostic factor in idiopathic membranous nephropathy. Therefore, it is suggested that early recognition of IgG level is indicative of renal changes that may increase the likelihood of preventing the development of diabetic nephropathy.

Key words: Type II diabetes, IgG, SDS electrophoresis.