Published September 1, 2026
| Version 1.0.0
Analysis code for single-cell RNA sequencing of a CRISPR-engineered endogenous Drosophila tauopathy model
Authors/Creators
-
1.
Yale University
- 2. Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA
- 3. Stephen and Denise Adams Center for Parkinson's Disease Research of Yale School of Medicine, New Haven, CT 06511, USA
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4.
Brigham and Women's Hospital
Description
Analysis code supporting the study “Transcriptional programs mediating neuronal toxicity and altered glial–neuronal signaling in a Drosophila knock-in tauopathy model.”
The repository contains scripts and notebooks for Cell Ranger preprocessing, Scrublet doublet detection, Seurat-based single-cell RNA-seq analysis, trajectory analysis, FlyPhoneDB, pySCENIC, OmicsIntegrator, and generation of selected manuscript results.
Associated sequencing data are available from GEO under accession GSE223345.
Files
Single-cell-RNA-seq-of-the-CRISPR-engineered-endogenous-tauopathy-model-main.zip
Additional details
Related works
- Is supplement to
- Journal article: 10.1101/gr.278576.123 (DOI)
Funding
- Aligning Science Across Parkinson's
- Parkinson5D: deconstructing proximal disease mechanisms across cells, space, and progression ASAP-000301