Code and derived data for cardiometabolic liabilities and erectile dysfunction: overlap-corrected Mendelian randomization and corpus-cavernosum cell enrichment

Version 2.0.0 contains the frozen R and Python code and aggregate derived data supporting a re-estimation of cardiometabolic liabilities against the 2025 European erectile dysfunction genome-wide association meta-analysis. It adds full-summary-statistic MRlap correction for participant overlap, winner's curse, and weak-instrument bias; rebuilt multivariable Mendelian randomization with conditional F, heterogeneity, and pleiotropy diagnostics; and donor-level scDRS enrichment using the GSE206528 human corpus-cavernosum single-cell atlas. Raw GWAS and GEO matrices are not redistributed. Effects derived from the 2025 erectile dysfunction outcome are standardized liability-scale effects and are not odds ratios. The archive does not establish an independent causal effect, molecular mechanism, treatment efficacy, or validated therapeutic target.