Liquid-Addressable Neurovascular Docking Interface: A Sequentially Dissolvable Dual-Plate Concept for Prevalidated Spinal Cord Graft Connection

Spinal cord repair requires vascular perfusion, barrier integrity, axonal crossing, electrical continuity, and safe host-graft integration. Existing scaffold, cell-transplantation, vascular biofabrication, and anastomosis research addresses portions of this problem, but final alignment and integration remain substantially dependent on biological self-organization.

This proposal introduces a matched dual-plate neurovascular docking interface. A graft-side plate and a host-side plate carry corresponding vascular and neural route coordinates. Temporary sacrificial vascular cores establish prospective lumen continuity, while longer-lived neural guidance filaments support directed axonal crossing. Mechanical keys or controlled magnetic forces provide alignment and temporary fixation; biological tissue, rather than the docking mechanism, must create the durable seal and connection.

Dedicated closed-loop liquids selectively dissolve individual temporary components only after predefined vascular, neural, material, and safety gates are passed. The primary hypothesis is that matched dual-plate docking with temporary continuity guides and state-triggered selective dissolution will improve stable, leak-free endothelialized channel continuity and persistent cross-interface neural conduction compared with unguided apposition, geometry-only alignment, or fixed-time degradation.

The proposal defines system components, experimental controls, measurable outcomes, provisional acceptance gates, staged in vitro testing, explicit stop conditions, and criteria capable of falsifying or narrowing the architecture.

This is an open, falsifiable, and unvalidated preclinical research hypothesis. It is not a clinical treatment, medical advice, surgical protocol, materials recipe, proof of safety or efficacy, claim of world-first priority, or claim of patentability.