Published August 20, 2026
| Version v1
Dataset
Open
THE HIDDEN MICROBE-PHARMACOKINETIC AXIS: NAVIGATING ERRATIC DRUG ABSORPTION IN CRITICALLY ILL PATIENTS
Authors/Creators
- 1. 1. United Medical and Dental College (Affiliated With Jinnah Sindh Medical University, Karachi) Pakistan.
- 2. 2. Rawalpindi Medical University, Pakistan.
- 3. 3. St George's School Of Medicine, Grenada, West Indies.
- 4. 4. Royal College Of Surgeons, Ireland.
- 5. 5. MD, Msc St. Georges University, Grenada, West Indies.
- 6. 6. Independent Researcher, Rochester New York. USA .
- 7. 7. Nishtar Medical University, Multan, Pakistan.
Description
Background: Critically ill patients routinely experience profound physiological derangements that significantly alter drug pharmacokinetics and pharmacodynamics. While fluid shifts and organ dysfunction are classically implicated, the gut microbiome has recently emerged as a critical driver of unpredictable drug absorption, giving rise to the field of pharmacomicrobiomics. Objective: This narrative review aims to comprehensively evaluate the mechanisms through which the dysbiotic gut microbiome in critical care settings hijacks the pharmacokinetics of enterally administered drugs.
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