JannaColt/WPI_determination: Weighted Performance Index (WPI) v1.0

Weighted Performance Index

The script computes the Weighted Performance Index (WPI) using pre-assigned weights for a pathogen panel. These weighting parameters are user-adjustable and can be modified manually.

The default weights currently implemented are grounded in the WHO fungal priority pathogens list to guide research, development and public health action (WHO, 2022). The scorecard utilized for this calculation can be accessed in the Supplementary Material Table S13 of the corresponding publication hosted on Figshare.

Input Data Structure: The script requires a tabular file (e.g., .csv or .xlsx) containing the inhibition data. The expected column structure is as follows:

Isolate_ID: Unique identifier for each evaluated strain or candidate tested. Pathogen: Name of the target pathogen tested. Important: The pathogen names must match the exact spelling and formatting used in the script's reference database to prevent matching errors. Replicate: Assay repetition identifier (e.g., Rep_1, 1, 2, 3), which the script uses to automatically calculate mean values and handle biological replicates. Inhibition: Measured inhibition zone diameter in millimeters (mm). (Optional) Condition: Growth condition or assay.

<img width="3952" height="5072" alt="Fig01_PanelB_vf3 4 drawio" src="https://github.com/user-attachments/assets/2695bfe7-d285-419b-b42b-092c7510e688" />

References WHO (2022). WHO fungal priority pathogens list to guide research, development and public health action. World Health Organization. Disponible en: https://www.who.int/publications/i/item/9789240060241