GiriNeoSepsisMimic™

GiriNeoSepsisMimic™ is an evidence-informed, algorithmic clinical decision-support reference designed to help clinicians systematically differentiate neonatal sepsis from infectious and non-infectious conditions that may present with similar clinical features.

The CDSS uses a safety-first, structured approach beginning with immediate assessment and stabilisation, followed by clinical classification, targeted differential diagnosis, rational investigations, serial reassessment and antimicrobial-stewardship considerations. It covers common neonatal conditions as well as selected uncommon but clinically important infectious, metabolic, neurological, gastrointestinal, endocrine, cardiovascular and inflammatory mimics. It also recognises that sepsis and a mimic may coexist.

The tool includes bedside discriminators, investigation pathways, management principles, counselling guidance, evidence grading, references, frequently asked questions, limitations and an explicit AI-assistance and governance statement. Its responsive, self-contained HTML format supports bedside use on computers, tablets and smartphones without external software dependencies.

GiriNeoSepsisMimic™ is intended to complement—not replace—clinical judgement, senior neonatal consultation, local antimicrobial policies and established neonatal sepsis protocols. It must never delay stabilisation, microbiological sampling or empiric antimicrobial treatment when neonatal sepsis is clinically suspected. The tool is evidence-informed but has not yet undergone prospective clinical validation as a diagnostic or prescribing system.