Cytotoxic and antiviral properties of 4,4'-bis-aminoalkoxybiphenyls

Zanoza Svitlana O., Bykova Tatiana I., Lyakhov Sergey A., Andronati Sergey A., Zholobak Nadiya M., Levandovskiy Igor A. Cytotoxic and antiviral properties of 4,4'-bis-aminoalkoxybiphenyls. Journal of Health Sciences. 2014;4(16):276-281. ISSN 1429-9623 / 2300-665X. DOI 10.5281/zenodo.21774

http://dx.doi.org/10.5281/zenodo.21774

https://pbn.nauka.gov.pl/works/597257

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http://journal.rsw.edu.pl/index.php/JHS/article/view/2014%3B4%2816%29%3A276-281

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© The Author (s) 2014;

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This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.

The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 15.11.2014. Revised 05.12.2014. Accepted: 25.12.2014.

CYTOTOXIC AND ANTIVIRAL PROPERTIES OF 4,4'-BIS-AMINOALKOXYBIPHENYLS

Svitlana O. Zanoza¹, Tatiana I. Bykova², Sergey A. Lyakhov¹, Sergey A. Andronati¹, Nadiya M. Zholobak², Igor A. Levandovskiy³

¹O.V. Bogatsky Physico-Chemical Institute of the National Academy of Sciences of Ukraine, 86 Lustdorfska Doroga, 65080, Odesa, Ukraine. E-mail sa.zanoza@gmail.com

²D.K. Zabolotny Institute of Microbiology and Virology of the NASU, 154D Acad. Zabolotny str., 03680, Kyiv, Ukraine. E-mail bti77@ukr.net

³Department of Organic Chemistry, National Technical University of Ukraine, Pr. Pobedy 37, 03056 Kyiv, Ukraine. E-mail lia@xtf.kpi.ua

Summary

Despite the high efficiency of the etiotropic antiviral drugs and antiviral vaccines they can lead to the selection of resistant mutant variants, initiate of evolutionary "arms race" [1] and pose a threat of the superinfections and epidemics. In this regard, the creation of means that enhance non-specific antiviral resistance is actual task and will be such in the future. The development of such agents – the functional analogues of amixyne (tilorone) – inducers of IFN type I is conducted in the past decades in O.V. Bogatsky Physico-Chemical Institute of the National Academy of Sciences of Ukraine. As an inactive model compound 4,4'-bis-[2-(diethylamino)ethoxy]bi-phenyl was synthesized in 2005 and unexpectedly appeared as an active antiviral and interferon inductor [2]. In this regard, analogues of this compound is of considerable interest from the point of view of the structure-properties relationships. These substances (R-A-4DP4-A-R, R – amino group of different structure; A = -(CH₂)_nO-, n = 2 - 6; 4BP4 - 4,4'-biphenyl) were synthesized via halogenoalkylation of 4,4-dioxybiphenyl with dihalogenoalkanes following  with amino dehalogenation.

Keywords: Cytotoxic; antiviral properties; aminoalkoksybiphenyls.