Prevalence of schistosome infection in a region of Madagascar regularlyundergoing mass drug administration: a cross-sectional study
Authors/Creators
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Krumkamp, Ralf
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Remkes, Aaron
- Hainasoa, Jacques
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Tahinamandranto, Rasamoelina
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Razafindrakoto, Anjarasoa Ravo
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Hey, Jana Christina1
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Winter, Doris
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Fischer, Natalie
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Gunga, Leonard
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Martel, Philippe
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Jouanard, Nicolas
- Andrianarinirina, Zo
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Rausche, Pia1
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Kutz, Jean-Marc1
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Doumbia, Cheick Oumar2
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Rakotozandrindrainy, Raphael
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May, Jürgen3
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marchese, valentina1
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Rakotoarivelo, Rivonirina Andry4, 5, 6
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Fusco, Daniela1
- RESAMP Project
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1.
Bernhard Nocht Institute for Tropical Medicine
- 2. ENSup
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3.
Beethoven-Haus Bonn
- 4. Faculté de Médecine
- 5. Laboratoire Pluridisciplinaire Santé Intelligence Artificielle
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6.
University Hospital of Lausanne
Description
Schistosomiasis is a parasitic disease primarily controlled by Praziquantel-based Mass Drug Administration (MDA) targeting school-aged children. This study aimed to generate a high-resolution schistosomiasis prevalence map in a region with regular MDA in Madagascar,identify at-risk groups, assess population knowledge, and explore risk factors to supportalignment with WHO guidelines. Conducted between July and October 2022 in the Districtof Vatomandry, Madagascar, this cross-sectional study included participants aged five andolder. Point-of-Care Circulating Cathodic Antigen testing determined infection prevalence.A choropleth map was generated to show the geographical distribution of schistosomeinfection across local communities. Individual risk factors were assessed using hierarchicalPoisson regression. The study included 1,215 households (5,200 participants) from 42 commu-nities revealing a high overall prevalence of 59%. Adjusted prevalence ratios (PR) indicatedhigher infection risks for farmers (PR = 1.17, 95% CI: 1.09–1.25) and older age groups (≥38 years:PR = 1.34, 95% CI: 1.16–1.55; against ≤15 years), while participants with higher education orknowledge about schistosome transmission showed a reduced risk (PR = 0.88, 95% CI:0.78–0.99). The results show high schistosome prevalence in adults, emphasizing the need toadapt strategies in endemic countries to meet the WHO’s 2030 goal of eliminating schistoso-miasis as public health problem.
RESAMP; Madagascar; East Africa / Indian Ocean; Interdisciplinary Pilot Project; schistosomiasis; tropical diseases; agriculture and health; neglected and poverty-related diseases
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Prevalence of schistosome infection in a region of Madagascar regularly undergoing mass drug administration a cross-sectional study.pdf
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