MetrINo
Published July 13, 2026 | Version v1
Project deliverable Open

Good practice guide including SOPs for measuring particle size and concentration of small (< 10 nm) nanoparticles and agglomerated or aggregated non-spherical objects as well as nanoparticle surface properties (amount, chemical composition, and homogeneity of the surface coating)

Description

This report serves as a comprehensive technical guide and a repository of best practices derived from the MetrINo project as deliverable D3 for the physical and chemical characterization of nanotherapeutics. As nanoparticles increase in complexity—varying in size, morphology, and surface chemistry—selecting the appropriate analytical tool becomes challenging, and standard operating procedures (SOPs) help to get reproducible results.

This report provides compiled SOPs developed within MetrINo for the reference materials provided in the project. A short overview of the material is given in section 2. Section 3 provides data on the right choice of measurement method compiled from the experiences in the project. The data is condensed into decision tables for each measurand, to make it easy for the practitioner to decide upon a suitable method. These tables also include materials not covered by the SOPs and were previously reported in the Metrino Acadamy series of webinars. Finally, sections 4 and 5 provide the tested SOPs for the dimensional and chemical characterization of nanoparticles. 

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D3 - Deliverable 3 MetRINo final-rev1.pdf

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Additional details

Additional titles

Subtitle
Deliverable D3

Funding

European Association of National Metrology Institutes
MetrINo 22HLT04